Unfortunately there's a rather large segment of the population that will vote for her based solely on the fact she's A) black and B) a woman just so that they can can prove to themselves how woke they are. They were able to check off one of those in 08 and 12
I think the last election showed that an unlikable woman is not a lock to win. Running against Trump won't be the same as running against McCain and Romney. Barack Obama was likeable, well spoken, and has some charisma (according to some). His wife doesn't have that.
It doesn't really matter who it is that survives the current cage match. The media and online powers will be pulling out all the stops to get them elected. If I didn't care about outcome, it would be an interesting event to watch.