I won't be shocked if we find simple life on Mars or Europa, Enceladus etc. I'd be rather surprised if we find multi-cellular complex life anywhere else in the Solar System.
JWST will just be on the cusp of getting exoplanetary atmospheric spectra that could detect ratios of water, oxygen, carbon dioxide, and methane that aren't easily explainable by anything other than life.
There's probably a trillion plus planets in the Milky Way. And billions of those are going to be in the liquid water goldilocks zone. However, when you factor in all the leaps and chances that have happened on Earth, and if a few of them are 1:1000 odds or worse, Eukaryotes to Prokaryotes, multi-cellular life, complex life, sexual reproduction, selection pressure for brains, then tools, then technology... then you can still run out of planets, and the answer to the Drake Equation can still be N=1...
We're also quite early in the age of the Universe. In terms of how long stars will last, or be around, we're not even 5% of the way into the stelliferous era. And much of the 12-13 billion years of the Universe's evolution hasn't been conducive to life. Waiting on Population II and III stars to get enough heavy elements to form planets and complex chemistry, the galaxies central black holes settling down and clearing out the core so they stopped spewing radiation in all directions, then the 4.3 billion years Earth has taken to come up with us could be about average, granted we've only got one data point, and we don't know if the dinosaurs were arguing about funding DASA. (Dinosaur Aeronautics and Space Agency) Although certain unnatural isotopic ratios would survive to this day if there was a technological civilization on Earth 65 million years ago. So it's probably likely we're the first.
We might be among the first everywhere, the "ancients" charged with farming the galaxy and seeding life elsewhere. Might be our mandate. Being "first" and "alone" is just as profound as finding out we've got neighbors IMO.