I've not had good experiences with GM products.
First was a Pontiac Bonneville. The engine was reliable enough and it ran strong, but many components attached to the engine weren't as well designed. In the ten years my parents had that car, it went through 3-4 alternators, at least one AC compressor, and multiple power window motors (there was other stuff, but those are the specific problems I can think of).
The 2nd was a Pontiac Grand Prix my wife owned when we got married. She replaced the transmission once and had it rebuilt once prior to us getting married. The ABS system failed. During the time it was failing, it would kick in even in a normal braking situation (hint: that doesn't help braking on dry pavement). It ran rough as hell for no apparent reason. The last straw was it trying to kill me in rush hour traffic on I66. The cruise control kicked in by itself and tried to accelerate from 10mph to whatever speed it wanted. I had to stand on the brakes while wrestling it to the breakdown lane. I shut it off and cranked it back up. Worked fine and then went haywire again. I repeated shutdown/crank process again and it was fine till I got home. I bought another car within the week.
I've owned three Toyotas (actually still have two of them). The 93 Paseo needed nothing but normal wear and tear items (tires, plugs, clutch, brake pads, etc) during the 120k miles I put on it (sold it with 196k miles) and 8 years I owned it.
The 97 4Runner has been equally reliable except for the rear axle seal I replaced in 2003. It's a common problem in 3rd gen 4Runners (and easy repair), but hasn't come back since. With 158k miles, I'd still drive it cross country right now if necessary.
My newest Toyota is a 2003 Camry. Other than a freak problem where the water pump leaked onto the pulleys, which contaminated the idler arm bearing and alternator bearing, resulting in the replacement of all three components, it has been reliable. Had I caught the leak early enough, it probably would've just been the water pump. With only 50k miles and two years of ownership (125k total miles), the jury is still out on that one.
In all fairness, the 1993 Nissan Altima I owned for a couple years was a lemon on par with the Pontiacs (worse actually), so I won't buy another Nissan either. I bought it with 50k on the odometer. By the time it hit 90k, it had a major oil leak, a significant water leak, no AC, and intermittent electrical problems. When I was offered $400 on trade-in when I bought the Camry, I was all too happy to take it.
There are a lot of American cars I'd like to own, but cars are too expensive to take risks on. I keep my cars for a long time and expect them to last (and not kill me...).
Chris