This has been discussed before in wider scope
http://www.armedpolitesociety.com/index.php?topic=56886.0but here I'm just discussing oral pain. I had some minor tooth issue a few months ago and the dentist's nurse recommended
3 Advils with 1 Tylenol. I tried that and it worked great, although I didn't have a lot of pain to start with. I was "getting in front" of the pain.
But I looked on the Internet and quite a few people endorsed this combination for oral pain, but nobody mentioned it with reference to other kinds of pain.
If it's Friday night and you have a toothache, it may be worthwhile to try this.