No. 4 buck has been my round of choice for home defense since I bought my home in 1993.
27 .24-caliber pellets is going to ruin the hell out of someone's day at household distance.
If I do ever need something heavier, there's the 5 rounds of 00 buck in the carrier. It's not the standard load, it's got an extra layer of 00 pellets, for a total payload of 12. Done with a roll crimp and card overwad.