Butt out. It's their business, not yours.
Yes, but. "Be there" for your friend. My experience, limited as it may be, is that men don't "open up" to friends as easily as women do when the chips are down.
Personal experience...one of our best friends had a problem with his son who attempted to take his life in a foreign country. Long story, I won't bore you with the details. My spouse speaks the language of the country the kid was in. I told him you HAVE to call (friend) and help him. I had learned of the problem through the wife. I said he needs you NOW, call him and offer your help with translation and getting through to the people near his kid who can help him. He called. The friend opened up. Long story short, it made our friends' lives easier through a very difficult time even if it was simply translation and contact skills.
I can't tell you what to do with your friend. Every situation is different. Just stay close in case he needs to talk.