Sorry to be the downer here, and you may yet be able to fix this, but I had this happen to a laptop at work about half a year ago (I'm ordered to give laptop users admin rights -blech). I can't recall the malware anymore, but after I discovered it, my spyware removal programs would not remove it. I went to all the internet sites that had manual removal instructions, followed them, and no luck. His computer was similar to yours in that he had hundreds of spy/ad/malware programs on it.
My final resolution was to pull all his data files to one of my test machines, scan them all to make sure they were free of bugs, then nuke the laptop and reinstall Windoze and the clean data files. I hope yours doesn't come to that, but in the end it may be the cleanest solution to give you a fresh, malware-free start.
If you use IE (or any browser) make sure it's set to the highest security/privacy settings and that you disallow all third party cookies at the very least. The safest bet is to disallow ALL cookies (and of course pop-ups), then add exceptions for the websites you want to allow in. Somewhat of a hassle to setup, but better than going through what you're going through now. Good luck!
