Assume a spherical cow. Actually, two identical, spherical cows, both 25 yards away from you. One cow you will be shooting with a Glock 19. The other you will shoot in the exact same place, at the same angle, with a .22 LR (say, a CCI Mini-Mag), from a 16" barrel.
Let us further assume you are neither whipping the guns forward, to increase velocity; setting your sights to 300 yards, to increase power; or turning them sideways, for a kill-shot effect. Both guns are stock, without any bayonets, flash hiders, or barrel shrouds, that would enhance killing-ness.
Which munition will most damage our spherical friends? Please support your answer with appropriate sources. Bribing super-delegates in order for your answer to win, is not allowed.
Thank you for playing.