Instead of "...and then run fast in the other direction immediately." I told her, "Spray, move because he's going to go for the last place he saw you, and then pick up whatever's handy and do your best to beat the p*ss out of him."
I gave my wife a Kimber LifeAct, and told her to use both shots, check for effect, and if it even starts to look like the guy's shaking off the effects, use her gun until he stops shaking off the effects. I carry one opposite my .357 with the same intent.
Right now she's 6.5 months pregnant with a bad back and an old hip injury, and after that's done there'll be several years of dealing with a small child that can't run very fast and that she can't carry fast enough to outrun most attackers. I've got a bad knee, so I can't do much in the running department beyond a few yards, either. As soon as the kid's old enough to run effectively, there will be lessons in running away on command and not waiting for mommy or daddy.