I've done some searching on the "Mississippian" culture of mound/town-building NAIs that seemed to dominate all the eastern N America save the coasts. Interesting as all get-out. Some of them even got to the point where they could use copper(1).
Every mound / site excavation indicates that it all fell apart a couple hundred years before the Europeans came calling. IOW, when the Pilgrims hit Plymouth rock, the NAI groups were more like the fallen Mayans than the Aztecs, development wise.
The plains Indians don't look like they EVER had much beyond what the Europeans saw when they arrived.
Also, I don't doubt disease spread steadily from the first landing on mainland N America. The Black Death spread even between groups that were not on good terms by means of infected, but ambulatory war-makers interacting with yet-uninfected adversaries. It spread faster at certain junctures due to the sea trade, but it is a model to compare.
Heck, one can even use the horse and firearms as proxies for disease. Once a group was shown to have access to either, one is certain that there was enough contact for disease to be transmitted. IIRC, the Sioux were at the ass-end of both the firearms & horse dissemination and managed to dominate becasue they put both together--in the 1700s, WAY before any Europeans dreamed of traversing the Great American Desert (AKA, Great Plains).
All in all, an interesting topic.
(1) Though it looks like when the mound/towns fell apart, they also lost the ability to fashion copper implements and were once again at a stone-age technology level.