So maybe epi in cardiac arrest is not all that hot either: http://www.medpagetoday.com/Cardiology/Arrhythmias/48884
As soon as I read that worse outcomes were dose-dependent, my first thought was, "well, the longer they're down, the more doses of epi they get.... I wonder if the worse outcomes might be related to length of arrest vs. epi administration...."
And sure enough...
Limitations
One limitation was the lack of information about why one-quarter of patients didn't receive epinephrine, Ewy said.
Another was the less favorable prognostic characteristics of those who did get epinephrine, he noted, writing that "they were older, less likely to have a witnessed event, and less likely to present with a shockable rhythm, and they had a longer duration of resuscitation (P<0.001)."
[emphasis mine]
I mean, realistically, cardiac arrest and resuscitation from it are incredibly brutal assaults on the body and brain. Between hypoxia/anoxia, CPR, defibrillation, and all the drugs we throw at the patient, then add on all the issues with reperfusion and stagnant blood, and I'm frankly amazed that anyone survives....
ETA: That's not to say that epi may not have some serious effects. The amount of epi we administer during a cardiac arrest, I'm surprised patients don't go straight into v-tach if we get a pulse back.