Around 90% of them died from disease. They lost control of two continents. In the USA they are the most dysfunctional minority group of all.
Oh, thanks for that, I meant to respond to that one as well.
I would say that for the Indians that did assimilate into the invading culture, it worked out well. (Eventually... What our country did to the
assimilated Cherokee was horrific.)
Of course, their culture is effectively gone now, but that's nothing to be concerned about, right? Just assimilate into the invading cultures and you'll be fine.