I have only shot red dot optics that had a 3 MOA dot. At the indoor range where I normally shoot, even with the lights on I had no trouble seeing the dot. If you aren't accustomed to shooting with a red dot optic, getting it aligned somehow feels different, almost backwards compared to using regular, open sights (at least, it felt strange to me). But actually seeing the dot wasn't an issue, and indoors I didn't need full brightness even with the lights on.
Outdoors, in sunlight, was a different story. I'm red-green weak, and in sunlight I can't see a red dot at all. And I don't think making the dot twice as big would make a difference. Outdoors, I need a green dot and that's the end of the story.