The Feds have been able to meddle in intra-state issues with impunity ever since that travesty of a SCOTUS ruling, Wickard vs. Filburn. Basically, it said that by NOT participating in inter-state commerce, a person was affecting interstate commerce, and was thus participating in interstate commerce by not participating in interstate commerce, which made them subject to Federal laws & regulations under the Interstate Commerce clause.
Yes, large swaths of our government ARE insane. But nonetheless, they have to power to impose their insanity on everyone.