I believe I can agree with all the suggested reforms.
I often hear "plea bargains save time and money".
Well, I have a hint for Federal prosecutors on a way to allow them to better use their time and save my tax money, have your boss in the Executive, lobby freaking Congress to quit passing unnecessary expansions of the list of Federal crimes (usually based on palpably stupid interps of the Commerce clause - thanks FDR, ya big Red), veto those that make it to his desk and rescind executive orders and such that have added to the workload.
1) If you feel lobbying is beneath you, just do your damn job and prosecute each and every case and pointedly, loudly and repeatedly explain, when the gridlock happens, why Congress is to blame for overreaching the Constitution.
2) Mail fraud and wire fraud are just ways of Federalizing crimes as well. As was said, prosecute the fraud at the state level for the act, don't bootstrap it to Fed. level using, ta da, the Commerce clause abortion. I also agree about closing arguments. "Closing", meaning "done". You give your summary, reiterate your points, and shut up and let the jury, the "deciders" do their job. You don't get a "last word" , your closing argument WAS your last word.
3) Until proven in a court of law they are the result of criminal acts, assets shouldn't be seized. If they must be sequestered until that determination is made, the accused should have recourse to at least use them as security for credit to make their case. If they lose, they are on the hook for the loan, if they win, the Gov. returns the assets AND pays the interest on the loan. (some industry will arise to accept that risk)
4) Overcharging is a blatant insult to the jury. If you can't make Murder 1, charge Murder 2, don't charge every lesser-included in the hopes the jury will split the difference when you fail to make you primary count stick.
5) I hate RICO, since prosecutors can't be trusted to use it narrowly as intended, scrap it. Sorry, no toys for you until you straighten up your act. Love, Your Dad, the American taxpayer
6) Civil means civil. When a criminal law is broken it offends the people as a whole who are then represented by their government. If the government cannot prove its case, it should devolve back upon the individual citizens to bring action on their own behalf, not for the next gov. prosecutor in line to get another bite at the apple. If you think you have a better shot by going through the regulatory courts, START THERE. Pick your best single shot and take it, you'll have done your job.