What's wrong with Asperger's?
(currently learning everything I can about precision machine shop stuff... - it's fun...)
Short answer: Nothing, insofar as guns and 2A rights should be concerned.
Long answer: It's part of the Autism Spectrum of disorders. Usually characterized, in part, by the person having impared ability to relate to and understand other people, especially being able to recognize differences in body language, tone of voice, and other non-verbal cues.
In terms of guns and the ability to be responsible with them, and not going crazy like the guy in Tucson, there's absolutely no connection to Aspergers. But there's plenty of people like my sister that would gladly use any tool possible to restrict access to guns to as many people as possible regardless of whether it is an appropriate tool or not.
That I'm pretty sure I don't have it makes little differnece to her. What I would admit to having though is Nerdbergers (aka The Knack).