Worn timing chain.
No offense to anyone in this thread, but i love it when folks start waxing nostalgic over how awesome and uncomplcated to work on older cars are. The level of self delusion needed to maintain that belief is amazing.
I'll take computers to work on any day rather then spend a weekend tuning and syncing some side draft webers in the hopes of getting a blazing 160hp out of a straight 6.
Self delusion my posterior.
I just went through "the routine" with my wife's 2000 Jeep Cherokee. One day it just started running rough ... VERY rough, as in feeling like it was running on four or five out the six cylinders. So I plugged in the OBD-II scanner and, lo and behold, it confirmed: Code P0306 ... which, when looked up, is "Misfire cylinder #6."
So WHY is it misfiring on cylinder #6? Well, of course, the scanner either doesn't know or isn't telling, so we resort to basics: An infernal combustion engine requires three things -- fuel, air, and a source of ignition. First guess -- getting to the spark plugs on this thing is a bear because of the coil-on-rail ignition system, so the original spark plugs had over 90,000 miles on them. So I changed the spark plugs. No joy.
A fellow member of an on-line Jeep club is a Jeep dealership tech. He produced a TSB that said the symptoms I had result when an exhaust valve gets carboned up and won't close completely. Solution: Top engine cleaner, followed by running it at high RPMs. Okay, three cans of top engine cleaner later, it won't run at high RPM because it's still misfiring and goes into "limp home mode" when it hits 2800 RPM.
That leaves injectors, and coil (of which there are three, but solidly mounted on a single -- and expensive -- rail assembly. A friend had a complete injector rail from the same year Jeep engine, so we swapped out the #6 injector. Nope -- no joy.
So the only thing left was the coil rail. $125 later, all was well. Electronic, computerized diagnostics didn't help a bit. And if there had been a conventional coil with spark plug wires, the new coil would have cost a lot less and it would tave take about one -quarter of the time to replace it.
Which helps explain why I still have and drive my 1988 Cherokee ...