While weed whipping around some trailer in the boneyard, I found myself standing in a patch of ankle high poison ivy. An immediate rundown with the neutralizer "Technu" and a cold shower helped, but 5 days later, like a clock works, the telltale blisters formed on the side of my face from ear to Adam's Apple.
Chemical treatment is my preferred method. Apply, wait, repeat. If you know what surgactants, spreader stickers, or crop oils are, this is an appropriate application for such an adjuvant, as the leaves are getting that waxy coating this time of year. Even a tank mix of broad spectrum and selectives may be warranted. Use a fine mist, apply to foliage to the point of runoff, that is a drop of the herbicide spray falling off the tip of each leaf.
In all herbicide applications, I recommend heavy watering and fertilization of the target species before application. Get the growth in High gear and systemic herbicides will be more effectiva.