Jesus could run for office, and the opposition would come up with something. It's the nature of today's politics.
Imagine if FDR were running for office today. Do you think the opposition wouldn't make an issue of his disability?
The only issue I know of so far that I have with Thompson concerns his judgement in the hearings on the Clinton campaign fund-raising scandals of 1996. He let John Glenn outmaneuver him, and agreed to make December the end date for the investigations. All Glenn had to do, then, was run out the clock.
Thompson's positives are impressive, even despite the fact that he's hairless (something you mentioned in another thread).
Imagine a Thompson/Hillary debate. Thompson looks distinguished, while Hillary looks, well, like Hillary. He has a sonorous voice, while hers is shrill. He has a presence that commands respect, while she invites hatred.
Only days ago I mentioned to a neighbor that Thompson might be running. The neighbor was so excited that he's been checking out the Thompson blogs and giving me daily briefings.