Yep, 100 ways to skin that cat, the key is just to train in what you pick, so you aren't figuring it out on the fly.
In class, one of the things we did was draw index and fire from retention into a target about 8" in front of you. Just so you know what the blast and shot are going to feel like with the gun essentially resting on your chest. Even with ear pro that was a loud shot.
Ben, I tend to agree with Douglas that if you can, get out of arms reach, then draw and fire, but I'm a relatively healthy, kinda big guy with at least a little grappling training and experience so I have that option. Not everyone does.
As an aside, since we're having the conversation, drawing from a pocket on a timer (and videoing myself doing it) is what made me give up on pocket carry as viable for my life. Too slow and awkward for me with the clothes I wear. It obviously works for some folks, but I couldn't get it to be fast and consistent enough.