sumpz - back in the 80s, I had a Toyota 4WD with the 22R 4-cyl. engine. For the first 75K miles,. I would mix my own "cleaner" out of various petrochemicals and add it to a nearly full tank in the late fall. I used about 8 oz. each of xylene, toluene, MEK, and mineral spirits, along with a 12 oz. bottle of methyl alcohol based gas line antifreeze.
After 75K, I did it in the early spring as well.
Truck cracked the block under the rear cylinder at ~150K but it finally threw a rod at ~190K and died.
Never had a problem with the fuel system lines or filter.