I use a special blend with 78% Nitrogen, instead of 100%.
Okay... okay... I keed. But someone has to say it every time a "N2" in tires? thread comes up.
In theory, the other 20% of lighter Oxygen could leak out faster, and there's a certain percentage of water vapor in an atmospheric compressor's source. While collected N2 is 'dry' etc. And it has a different/better expansion coefficient when heated/cooled meaning tire pressure will vary less.
So yes, it's "better", however, it's rare that it's X amount "better" as compared to the price you pay for an N2 fill, and the increased life of the tire due to it deflating more slowly, and not oxidizing on the inside as much due to no O2 or moisture being in there.
I'm skeptical. I suspect that N2 fills alone probably extend the life of your tire by a few months, statistically speaking. I'd only do it if it was free, or the same price as a for-pay air-compressor, like $.50 etc.