I changed my Outlook new mail notification to Homer Simpson saying 'OH DEAR GOD NO!"
It was fine until one day I had the group president and business development director in my office reviewing an animated presentation I was doing for them.
I had to turn the sound up, and you guessed it. REALLY loud, too.
Boss got this funny look on his face and asked "That's not going to be part of the presentation, is it?"
The BD director was a Simpsons fan, though, so he got it and was cracking up.