That ad has been playing around here. It's actually pretty effective highlighting Trump bufoonery, not that no one has seen it before. Clinton has also been running several different ads showing the warm, fuzzy Hillary that cares about ALL Americans and will bring parties together to solve all our problems. A natural rebuttal would be clips of her expressing her pride of having enemies (Republicans, NRA, etc), laughing about putting coal miners out of work, screeching at the woman who questioned her at a campaign event, etc, etc, etc. The only response by the Trump campaign thus far is a rather lame one regarding the "deplorable" comment.
Nor have there been any ads pointing out the crooked Clinton Foundation and speech fee deals.
The NRA has run a couple decent anti-Clinton ads, however.