I like walking my dog in the pre-dawn hours when skunks are often about. Trouble is, I can't see and avoid them. Fortunately, usually they run into the small storm drain culverts that run under driveways. 80% of the time when they spray, they miss. Rarely (only once in 13 years of daily walks), the skunk missed the dog and hit me. A couple of times when I was out stargazing, my dog actually alerted me to a skunk that was ambling right towards me. Skunks are incredibly oblivious and I would not be surprised if one wandered straight into me, and would only spray me after I shriek in surprise.
Some skunks are so dumb it becomes a problem. Once one was blocking my driveway when I was late for the train to work (and missing a train by 15 seconds is bad when they run only once every 15 minutes). I was honking and honking my horn but it just stood there like it was deaf. And I seriously did not want to have to deal with a squished skunk in the middle of my driveway. Another time, I was testing out a night vision monocular, and saw a skunk on a neighbor's yard across a very large draining ditch, digging up its lawn. I sat there for like 60 seconds just staring at it through night vision, wondering when it would notice me. Finally it did, and this skunk was aggressive. It started running towards me, and stood there hissing. But it made no attempt to spray me. Thankfully the big drainage ditch kept things civil... had it not been there, I would have hightailed it out of there as fast as I could. But I just sat there chuckling as it hissed and puffed trying to scare me off. That was also the biggest skunk I ever saw in my life.
One other issue I've had with skunks, is they find their way into squirrel traps. I found a technique on YouTube that works well: approach slowly with a beach towel covering your whole body. Skunks are so dumb that while they will see you, they won't perceive you as a living creature and will just look at you and not react. Then carefully cover most of the trap with your towel, slowly open the trap door. and back away just as slowly.