"Car goes in for a tuneup. They jack it up, drop the complete front end, and replace it. Design it right - Maybe what, a dozen bolts, and a single big electronic umbilical (with a separate high current wire for the starter). One man could probably R&R inside a half hour, given the correct tooling (like a lift that'll go xyz)..."
Believe it or not it's been almost done before. VW uses the umbilical pattern for their wiring, so did Chrysler with the 2.2/2.5 cars thought there are a few "body connections".
If I ever wanted to change the engine on my Shadow, provided I already had another transmission, I can see it being done in about 2 hours barring the usual issues (frozen exhaust bolts, etc.).
If a car like a Fox Mustang were kitted up right with a VW style wiring harness and say a turbo four (small, easy to move) I'd say a swap could be in and out in less than thirty. Unhook fuel, exhaust, coolant, wiring, u-joint... pull motor and tranny, replace, rehook, refill, viola.