Power generation is nice, half-life is about 25% though. Extra shielding for technicians can be removed just prior to launch, though it's gamma decay is considered "negligible". Only real question is would the extra lifting capacity for more isotope material be more or less expensive than the cost difference between producing Pu238 versus Sr90. On the flip side, if you designed the instrumentation of the craft to operate at the expected power output around say year 50, accounting for both decay of the isotope and the thermocouples, then that huge amount of extra power at the beginning could be diverted to something else. Say an ion thruster?
Pure Stronium-90 - 0.921 Watts/gram - Half-life 28.8 years
Pure Plutonium-238 - 0.560 Watts/gram - Half-life 87.7 years
Stronium Titanate - 0.536 Watts/gram
Plutonium(IV) Oxide - 0.540 Watts/gram
ETA: Oooo... Americium 241. Needs about 18mm of lead shielding and much lower thermal output, but it's half-life is absurd.
Pure Americium-241 - 0.140 Watts/gram - Half-life 432.6 years - Price: $1500/gram
It's the most common byproduct in nuclear waste. I was just imagining some 20 kilogram (not counting shielding) rods of Am241 for a personal RTG. Have it trickle charging a large battery bank, and replace the thermocouples every decade or so, and I'd have a personal home RTG that would last not just the rest of my life, but the lives of several generations of my progeny.